▶What are the major cognitive domains and how do you test each one?
Attention: ability to focus and sustain focus. Test with Continuous Performance Test (respond to targets), Digit Span (repeat numbers forward/backward, tests working memory), or TOVA (computerized vigilance test). Memory: short-term (hold info briefly), working (manipulate info), long-term (consolidate and recall). Test with digit span, California Verbal Learning Test (CVLT, learn and recall word list), Rey Auditory Verbal Learning Test (encode/decode/recall auditory material), or paired-associate learning. Executive function: planning, problem-solving, cognitive flexibility, response inhibition. Test with Wisconsin Card Sorting Test (categorize by rule that changes), Trail Making Test A/B (connect numbers or numbers/letters in order, B tests switching), or Delis-Kaplan Executive Function System (DKEFS). Visuospatial: mental rotation, visual-spatial relationships. Test with Block Design (arrange blocks to match a pattern), Rey-Osterrieth Complex Figure (copy a complex figure, then recall it from memory), or visual-spatial subtests of IQ tests. Language: naming, comprehension, repetition, fluency. Test with Boston Naming Test (name pictures), Token Test (follow increasingly complex verbal instructions), or Boston Diagnostic Aphasia Exam (comprehensive language evaluation).
▶What is the difference between dementia, delirium, and depression, and how does cognitive testing help differentiate?
Dementia: progressive, permanent loss of cognitive function in alert, conscious patient. Insidious onset (weeks to months), slowly progressive, irreversible. Causes: Alzheimer's disease, vascular dementia, Lewy body dementia, frontotemporal dementia. Testing shows global decline (multiple domains affected), especially memory. Delirium: acute confusion with impaired attention and consciousness. Abrupt onset (hours to days), often reversible. Causes: infection, medication, metabolic disorder, hypoxia. Testing shows poor attention (cannot sustain focus), disorganized thinking, variable performance. Depression: mood disorder with cognitive complaints. Onset variable, reversible with treatment. Testing shows normal attention but poor motivation (low performance), inconsistent effort, no structural memory loss. Distinguish: dementia = progressive, global, irreversible; delirium = acute, reversible, attention-focused; depression = mood-driven, reversible. Cognitive testing is part of the differential; MRI, labs, and medical history are also essential.
▶What is a Mini-Cog or Montreal Cognitive Assessment (MoCA) and when do you use brief vs. comprehensive assessment?
Mini-Cog (3-minute screen): clock drawing test + 3-word recall. Sensitive to dementia; used for rapid screening in clinics, ERs, or primary care. High sensitivity (detects most dementia) but lower specificity (false positives). MoCA (10-minute screen): tests attention, memory, language, visuospatial, executive function. More comprehensive than Mini-Cog; used in neurology clinics for quick cognitive assessment. Both are brief screening tools; they identify that a problem exists but do not pinpoint which domain or severity. Comprehensive neuropsychological testing (2–4 hours): multiple tests in each domain (attention, memory, executive, language, visuospatial, processing speed), used when detailed diagnosis or localization is needed (Alzheimer's vs. vascular vs. Lewy body?) or for return-to-work/return-to-drive clearance, or legal/disability evaluation. Choose based on clinical question and time/resources available.
▶What is aphasia and how does it differ from other cognitive language disorders like dysarthria or apraxia?
Aphasia: language disorder due to brain damage (usually left-hemisphere stroke, TBI, tumor). Affects language production and/or comprehension. Subtypes: Broca's (expressive, non-fluent), Wernicke's (receptive, fluent but nonsensical), conduction (repetition difficulty), anomia (naming), global (both expressive/receptive severe). Assessed with Boston Diagnostic Aphasia Exam or similar. Dysarthria: motor speech disorder (weakness, coordination problems in muscles controlling speech). NOT a language disorder; language is intact but speech is slurred, slow, nasal, or breathy. Assessed by speech intelligibility, articulation clarity. Apraxia of speech: motor planning disorder (difficulty programming speech movements), not muscle weakness. Speech is slow, effortful, inconsistent errors. Tested by repetition vs. spontaneous speech (discrepancy suggests apraxia). All three can co-occur post-stroke; distinguishing them guides treatment (aphasia = language therapy, dysarthria = articulation drills, apraxia = motor planning drills).
▶How do you assess executive function deficits and what do they mean clinically?
Executive function = planning, problem-solving, cognitive flexibility, response inhibition, working memory. Assessed with: Wisconsin Card Sorting Test (ability to shift categories when rules change, tests flexibility), Trail Making Test B (switching between numbers/letters tests flexibility), go/no-go tests (inhibition), Stroop test (ability to inhibit prepotent response), Delis-Kaplan Executive Function System (comprehensive). Deficits indicate: prefrontal cortex dysfunction (planning, impulse control, social behavior impairment), difficulties returning to work or living independently, risk of poor decision-making or safety issues (driving, finances). A patient with frontal lobe stroke may score normally on memory but have poor executive function (can remember things but cannot plan a day, impulsive, poor judgment). Clinical implications: may need external structure (written schedules, reminders), supervision for safety, or workplace accommodations (highly structured tasks, reduced decision-making demands).
▶What is processing speed and why is it clinically important?
Processing speed = how quickly a person perceives information, processes it, and responds. Measured by simple reaction-time tasks (press button when you see a light) or timed cognitive tests (Trail Making Test time, coding/symbol substitution speed). Slowed processing speed indicates: brain injury (TBI, stroke), dementia, multiple sclerosis, Parkinson's disease, or normal aging. Clinical importance: affects overall cognitive efficiency (even if memory and attention intact, slow processing impacts learning, work speed, conversation fluency, safety in driving). A patient with slowed processing but intact memory may struggle in fast-paced environments or multitasking. Predict functional outcome: normal processing speed + normal memory = good recovery potential; slowed processing + low memory = higher disability. Monitor over time; processing speed often recovers partially post-stroke but may remain slow in progressive disease (MS, Parkinson's).
▶How do you use standardized testing to diagnose Alzheimer's disease vs. other dementias?
Alzheimer's: earliest sign is memory loss (short-term first, then long-term), initially normal attention and executive function. Testing shows early decline in memory subtest, spared attention/executive. MRI shows hippocampal atrophy. Vascular dementia: cognitive loss corresponds to location of stroke(s). Variable pattern (may have memory + executive dysfunction). MRI shows multiple infarcts. Lewy body dementia: early hallucinations, Parkinsonism (rigidity, tremor), fluctuating attention, memory less affected early. Testing may be more variable day-to-day. Frontotemporal dementia: early personality/behavior change and executive dysfunction, memory relatively spared early. Testing shows executive and language impairment. Parkinson's disease dementia: motor symptoms first (rigidity, tremor, bradykinesia), cognitive decline later, pattern similar to Lewy body. Testing alone cannot diagnose; differential diagnosis requires: cognitive testing pattern, symptom history (memory first vs. behavior first vs. movement first), imaging (MRI/PET showing atrophy pattern), and biomarkers (CSF, PET imaging for amyloid/tau).
▶What certifications and training paths exist for cognitive and language assessment?
Neuropsychology: PhD or PsyD in clinical psychology (5–7 years), followed by 2-year postdoctoral fellowship in neuropsychology, then board certification (ABCN = American Board of Clinical Neuropsychology). Scope = comprehensive cognitive/neuropsychological evaluation, brain-behavior relationships, neuropsychological report writing. Speech-Language Pathology: master's in SLP (2 years), CCC-SLP + fellowship, then specialization in cognitive-communication disorders (aphasia, traumatic brain injury language impairment). Occupational Therapy: master's or doctorate in OT (2 years), NBCOT certification, then specialization in cognitive rehabilitation. Neuropsychology technician: high school + neuropsych tech training (1–2 years), administer tests under neuropsychologist supervision. Scope of practice varies by credentials and state; comprehensive cognitive diagnosis requires a PhD or PsyD psychologist or neuropsychologist.