Selective serotonin reuptake inhibitors increase available serotonin by blocking its reabsorption. Serotonin dysfunction is implicated in depression pathophysiology.

What's the difference between SSRIs and SNRIs?

SSRIs affect serotonin only. SNRIs (serotonin-norepinephrine reuptake inhibitors) also affect norepinephrine. SNRIs may help anxiety and pain better.

How long until antidepressants work?

Benefits typically appear after 2–4 weeks of consistent use. Full therapeutic response takes 6–12 weeks. Early discontinuation prevents symptom improvement.

Are antidepressants addictive?

No. Antidepressants do not create addiction or dependence. Discontinuation requires gradual tapering to avoid withdrawal symptoms, not due to addiction.

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Antidepressant Medication for Depression: Types and Mechanisms

Peter Kolomiets

|April 2, 2026|Updated Apr 13, 2026|7 min

Antidepressant Medication for Depression: Types and Mechanisms

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References

Gitlin M (2009). Selective Serotonin Reuptake Inhibitors: Efficacy and Adverse Effects
Hillhouse TM, Porter JH (2015). Pharmacology of Antidepressants: Mechanisms of Action and Clinical Effects

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Antidepressant Medication for Depression: Types and Mechanisms

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